chloropyramine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	606	59-32-5

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

chloropyramine
chlorneoantergan
chloropyribenzamine
chlorpyramine
halopyramine
chloropyramine hydrochloride
chloropyramine HCl

Molecular weight: 289.81
Formula: C16H20ClN3
CLOGP: 4.02
LIPINSKI: 0
HAC: 3
HDO: 0
TPSA: 19.37
ALOGS: -2.82
ROTB: 6

Drug dosage:

Dose	Unit	Route
0.15	g	O
20	mg	P

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Vaccination site reaction	60.96	46.14	8	707	121	63488186
Pleural neoplasm	52.51	46.14	8	707	363	63487944
Cranial nerve disorder	49.29	46.14	8	707	547	63487760

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Vaccination site reaction	61.54	43.99	8	826	121	79743433
Pleural neoplasm	53.16	43.99	8	826	360	79743194
Carcinoembryonic antigen	46.07	43.99	6	828	92	79743462
Carbohydrate antigen 15-3	45.89	43.99	6	828	95	79743459
Cranial nerve disorder	44.33	43.99	8	826	1102	79742452

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	D04AA09	DERMATOLOGICALS ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC. ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC. Antihistamines for topical use
ATC	R06AC03	RESPIRATORY SYSTEM ANTIHISTAMINES FOR SYSTEMIC USE ANTIHISTAMINES FOR SYSTEMIC USE Substituted ethylene diamines
ATC	R06AC53	RESPIRATORY SYSTEM ANTIHISTAMINES FOR SYSTEMIC USE ANTIHISTAMINES FOR SYSTEMIC USE Substituted ethylene diamines
MeSH PA	D018494	Histamine Agents
MeSH PA	D006633	Histamine Antagonists
MeSH PA	D006634	Histamine H1 Antagonists
MeSH PA	D018377	Neurotransmitter Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	8.62	Basic
pKa2	4.33	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Focal adhesion kinase 1	Kinase	Q05397	FAK1_HUMAN		Kd	6.24		CHEMBL

External reference:

ID	Source
D07195	KEGG_DRUG
20861	RXNORM
C0055445	UMLSCUI
CHEBI:94767	CHEBI
C4C	PDB_CHEM_ID
CHEMBL1194287	ChEMBL_ID
DB08800	DRUGBANK_ID
C004664	MESH_SUPPLEMENTAL_RECORD_UI
25295	PUBCHEM_CID
179	INN_ID
6170-42-9	SECONDARY_CAS_RN
2K3L8O9SOV	UNII
005999	NDDF
006000	NDDF

Pharmaceutical products:

None